What is your favorite restaurant in Vancouver?

Tojo's Restaurant The best sushi . A Classic

S.R. has got it down. I would just add a couple of my favourites, Fable Kitchen (almost next door to Maenam) definitely sit at the open kitchen bar; Osteria Savio Volpe (a little off the beaten track but worth it); and last but by no means least Il Giardino - an Italian staple on the Vancouver food scene for decades (same owner). Ask for Bobby, he will make sure you get a table.

I had dinner at Forage on Robson Street, it was delicious and they also have a great selection of local wines.

One approach for you would be to check the Scout 25 - just do a web search to find the site. Personal favourites of my own (that I don't see mentioned in others' answers) are La Quercia, with the tasting menu the standout, Cinara, which also has a tasting menu, Maenam Thai Restaurant, both locations of La Mezcaleria, Juniper, West, Wildebeest, and Ask for Luigi Restaurant. One meal left on earth? I'd eat it at La Quercia or maybe Hawksworth Restaurant.

Las Margaritas, The Bimini, Bridges Restaurant on Granville Island

Vij's Rangoli- either Rangoli or Vij’s

Vij's Rangoliand Tacofino Gastown! 

Vancouver is  foodie heaven!!! There are so many fantastic restaurants! Vij's is TOP NOTCH as it is Vikrim Vij's mighty throne and all of the food is incredible. Also, Toji sushi Vancouver is one of the top restaurants in Canada. If you are looking for any more places including brunch, coffee, lunch, more dinner etc there are more than enough spots to satisfy all of your cravings. https://goo.gl/8MGc6L 

https://goo.gl/8MGc6L

Wonderful (modern) Indian food at VJ's Island Foods new restaurant on Cambie Street.

Vancouver has more than 5000 restaurants - something for every taste. Try Chambar Restaurant, Vij’s, Le Crocodile or, if you'd like to sample some Aboriginal food, Salmon n' Bannock on West Broadway. Enjoy!