Best areas in Singapore for a couple on vacation?

Infinity pool at Marina Bay Sands, Ocean Restaurant at S.E.A. Aquarium & Adventure Cove Waterpark, Singapore flyer, cable car, Skyline Luge Sentosa, Adventure Cove Waterpark, get a fish pedicure, Gardens by the Bay, Chinatown for dim sum, Haji Ln, Boat Quay, and do a river cruise...

Must visit Marina Bay Sands, night safari, singapore flyer, Jurong Bird Park and Sentosa Island. For nightlife go to the Clarke Quay area for restaurants and bars.

If you're after great nightlife and restaurants then your best bet is to stay in the Tanjong Pagar and Chinatown areas. You could consider Duxton Rd or Ann Siang Hill for example. The Club St area is very popular at night on weekends and the area is also dotted with trendy cocktail bars and new restaurants. Pretty much most of the best new openings of recent times are concentrated in this part of town.