Hey John, Hwy 101 is a beautiful drive, but since you have just 6 days I'd suggest taking I-5 to Grants Pass then 199 to Crescent City. The Redwood National Park is worth the trip. Then travel south on 101. Take 101 through Eureka and Ukiah. Cut over to 128 and follow it throught the wine country through Calistoga cut off on 29 and head to Napa. Then follow 37 through the wetlands along the upper Bay to connect with 101. Follow 101 into San Francisco over the Golden Gate Bridge. Enjoy the drive.
John Thanks Debbie however we have up to 10 days is there anything else you could recommend. Thanks Again John