Here are a few things you could do:

• Neumos: One of Seattle's best rock clubs.  Go to a rock show here
  
• Moe Bar: then come next door here for drinks.  Edgy, loud, hipster joint, young people. Stand up at the bar for stiff drinks before you go see a rock show. Loud, attached to Neumos.
  
• Space Needle: love this icon. 8th most photographed thing in the world - just turned 50!  It's touristy - but its actually really cool. I just took my nephew after not having been there for a decade or more. Sorta spendy, but worth it!  The restaurant up top has done a full 180 and is actually quite good.
  
• Smith Tower: observation deck is a unique view
• Bainbridge Island Ferry: a must do in seattle (only if it's sunny)
  
• Seattle Art Museum: The newly refurb-ed art museum is great.  Getting better every year.... the remodel is substantial. Check out the sculpture park on elliott bay too - also part of SAM.  Go SAM!
• Ride the Ducks of Seattle: hilarious and fun. we rented one for a birthday one year and partied like it was 1999
  
• Experience Music Project: music museum.  Cool spot even if touristy... will be fun for the adults and kids alike.
  
• Seattle Public Library - Central Library: great architecture - rem koolhaas. make sure to go INSIDE. stunning
  
• Fremont Troll: classic weird seattle in the Fremont Neighborhood
  

On my last trip to Seattle I discovered an amazing restaurant:  Local 360  SO GOOD!

Some other places to check out:

• Gas Works Park is an awesome place to checkout, and get some amazing views of the Seattle skyline. Plus, if you've ever seen 10 Things I Hate About You back in the 90s you'll appreciate it. 
• Seattle Underground Tour. You said you didn't mind touristy--well this is it. Little did you know, and most people in Seattle don't know this, but Seattle is built on top of itself. This is a pretty sweet little tour. 
  
• Seattle Gum Wall is a must see. Disgusting, but a classic  Pike Place Market attraction. 
  
• Pyramid Alehouse right by  CenturyLink Field is a great place to grab a good beer, as well as  Mac & Jack's Brewery in the Redmond area. 
  
• Pike Brewing Company. Yeahhh another brewery. Check em' all out. 
  
• Original Starbucks is a great spot in  Pike Place Market and then follow it up with the best chowder/soup you'll ever have at  Pike Place Chowder. 

There are a ton of restaurants too, it just depends on what your'e looking for. Too much to list here, unless you're looking for something specific.