Looking for luxury and prime location
Booking.com has a list of recommended places to stay in Santa Margherita Ligure. Based on guest reviews, the top 3 hotels are:
Also check out Suites Margot, Sabini Rental-Affittacamere, Sunnyhouse apartments and Appartamento Splendid
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How about an apartment like this one? https://www.homeaway.com/vacation-rental/p990972
When in Santa Margherita be sure to check out nearby Portofino which has long been a favorite of wealthy jet setters. It is a delightful spot. Camogli is another small seacoast town worth some of your time.