what is the best place to stay over night in between the two cities
Staying in San Antonio and then leaving there to head to Houston George Bush Intercontinental airport to fly out. What would be the best place to visit in between those cities and stay the night before flight.
If you really want to make it a two-day trip, I'd detour a bit to the north of IH10 and stop in Round Top or Brenham. Both are nice little towns with some interesting things to see. Round Top has a number of art galleries/studios and antiques stores. There are also some nice small hotels, B&Bs, and good restaurants. It's also the home of the Winedale Historical Center, where, if you're there at the right time, you can see Shakespeare performed in a barn by a company of acting students from the University of Texas. I'm not as familiar with Brenham, but friends tell me that it also is a pleasant place for a short visit, as long as you aren't looking for big-city entertainment.