For the truly artsy/hipster scene, check out Klubovna 2.Patro (http://www.2patro.cz/) Great DJs, cocktails and events! 

Also try Palác Akropolis (http://www.palacakropolis.cz/) for a true 'underground' scene and great live acts, Black Angel's Bar Prague (basement/speakeasy style bar below the old town square), and Radost FX. 

Within the centre in Old Town Square by Staroměstská there's a cool bar that spirals downwards called Chapeau Rouge that is fun.  Nearer the Pražský orloj is Cafe Popo that is a CHEAP cocktail bar.  To get here you have to go in a hostel alleyway but is a good laugh.  It's opposite Double Trouble.

But a bit more out there, you absolutely cannot miss Cross Club.  It's an easy metro ride to Nádraží Holešovice and is an unmissable 'dive' bar I think.  It's also near Mecca which is a proper club nearby

Hi Bridget!

As mentioned before, Cross Club, Palác Akropolis or Radost FX are great spots if you wanna dance the night away. And if you prefer just to go for a drink, then definitely try Parlour or Hemingway Bar. And let me know :-)

Have fun in Prague,
Tereza

I really liked Vinárna U Sudu. We walked past it many times thinking it was a tiny bar (when you look in the front entrance, you only see a small bar to the left with about 8 stools to the right). 

After checking it out, we realized that you can go underground about 3 levels and there's several different rooms - all very cave-like with stone walls. 

I can't comment on the music (I don't really remember!) but this is a bit outside of the 'touristy' area and in my opinion a hidden gem. Plus the beer and wine are about $1 USD! 

I would recommend the Cloud 9 Sky Bar & Lounge on top of the Hilton which is a great place for Saturday nights. Some like the music on offer at Lucerna Music Bar but I would follow the already recommended Palác Akropoliswhich is excellent