We are looking for a nice hotel in Prague for 4 nights in October 2015, centrally-located and no more than $150.- a night! Any recommendations?
Try the Jurys Inn Hotel, Prague City Centre - it is quite central, near two metro lines and numerous tram options. Plus you could walk to/from the city centre in about 10 min so it is a great location.
Additionally, Hotel ibis Praha Mala Strana is near one metro line, numerous tram options but is perhaps 15/20 min walk from the centre.
Their rates vary so check their site for your intended dates!
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