Driving route

I'd suggest:
1. Take I-295 then I-95 southwest to Christiana (Delaware)
2. Go left/ south onto 7 then continue straight on 1, passing through or near Bear and Dover (Delaware) (or use whatever route is convenient to pick up 1 from your location).
3. Just north of Milford (Delaware) leave 1 and follow 113 to Pocomoke City.
4. Continue on 13 (Ocean Highway), passing through or near Onley, Nassawadox and Cheriton to Chesapeake Bay Bridge-Tunnel.
5. When you reach the other side, follow 13 through the eastern outskirts of Norfolk then go left/south on I-64 to meet I-264. Go right/west.
6. Stay on I-264 through the city, continue briefly on I-664 west then take 58 west.
7.  Follow 58 west, passing near Suffolk, until you meet I-95 just north of Emporia (Virginia). Take I-95 south.
8. Follow I-95 south, passing through or near Smithfield (North Carolina), Fayetteville (North Carolina), Florence (South Carolina), Santee (South Carolina), Walterboro, Savannah, Jacksonville and Palm Coast.
9. Leave I-95 in Daytona Beach and go right onto I-4 to Orlando