From Toronto to Nashville is about a 12 hour drive and you might be able to do it without any overnight stops - not that I would ever recommend that. The shortest route 764 miles. This route has tolls, and is in a different time zone. Take ON-403 W, ON-401 W, I-75 S, I-71 S and I-65 S This route takes you north of Lake Erie to Detroit and then to Toledo (Ohio)Cincinnati and Louisville