Depending on the route taken, Lincoln (Nebraska) to Oklahoma City is roughly 430 to 460 miles. It'll take a minimum of 6.5 hours driving time without traffic delays or any rest/food stops. Route option 1 1. From Lincoln take I-80 west and leave at J353. Take 81 south towards McCool Junction . 2. Follow 81south to just north of Salina where it becomes I-135. Continue south on I-135. 3. Stay on I-135 south to and through Wichita then continue south on I-35 (Purple Heart Trail, toll). 4. Stay on I-35 until you reach Oklahoma City. Route option 2: 1. Take 77 south from Lincoln via Junction City until you meet I-35 near El Dorado. 2. Take I-35 towards Wichita then stay on it to Oklahoma City.