Take I-10 over. Plan to stay in Biloxi. Navigate to Cafe Dumond in New Orleans and take a carriage ride from Jackson Square in the French Quarter. Continue on I-10 to I-49, I-20 to I-40. That is a great drive. Be safe. Have plenty of water.
I would check the hotels in the Biloxi area. It is a great drive along g I-10. IP Hotel and Casino is fun and beautiful. Stay on low floors. If you are a Hard Rock Hotel and Casino member, then stay with them. It is worth it to get the Rewards Cards in Biloxi. Biloxi is nice.