Driving north from Miami Beach to Greenville SC. Most convenient place to stop with two small pets. Just an overnight. would like a good restaurant suggestion as well
Stylistically we;d prefern something 4-5 stars pet frendly
Stop in Saint Augustine and take the time to drive over to the historic part of town. It's only 20 minutes off I-95. Then, if you want something sweet & delicious, stop at Crème de la Cocoa, a dessert shop by a Food Network pastry chef. It's incredible! I'm sure there is a Kimpton Inn around there as well.
The halfway point between Miami Beach and Greenville is around Saint Marys and there is a pet friendly hotel (Riverview Hotel) there (they have cats) but it isn't a big fancy hotel - it's kind of old. There is a restaurant there and there are lots of other places to eat in town - it is a nice historic small town but it is a little way off the interstate. You could also go farther north to Brunswick or Kingsland or south at Fernandina Beach. The most reasonable three star place that I found on the direct route in this area which is pet friendly (for an extra fee) was the Hawthorn Suites by Wyndham Kingsland but they charge $35 per pet per night. I have not stayed there, but I have stayed in the Hampton Inn in Hampton Inn Amelia Island also is pet friendly for a pet of less than 25 lbs and the require a $50 deposit.
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The Residence Inn is quite a way out on the beach - I haven't eaten in any restaurants out there. Mostly when we visit we eat in town. Most recently we ate at Timoti's which is very casual and is only open until 8 pm on weekdays and Saturday. Have also eaten at Bretts (nice views) and the Marina Restaurant which is in an old historic building. My sister and brother-in-law took us out to Kabuki Japanese Steakhouse & Sushi which is closer to where you are staying but they like sushi better than we do.