Hi Susan, I would stop at one of the hotels in Kingsport (Tennessee) TN, close to I-81. Here are 3 to consider:
La Quinta Inn & Suites by Wyndham Kingsport
Sleep Inn & Suites Kingsport
Comfort Inn South
You would have driven around 9.5 hours when you arrive in Kingsport from New Brunswick . Kingsport is about 4 hours from Nashville
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susan
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susan First time heading southwest out of Jersey so not sure about traffic flow. We were hoping to make it to TN so Kingsport sounds good. Appreciate your suggestions. Will check them out!