Drive from Chicago to Tunica, Mississippi. Stay at Gold Strike Casino&Hotel. Drive to Biloxi, Mississippi. Stay at Beau Rivage Casino&Hotel. Make your way across I-10W. Use Hotwire.com to make reservations along I-10 after 4pm each day after you are tired of driving. Always stay on the West side of the city so you don't fight traffic in the morning. Keep a case of water in the car at all times. Start driving at 4am. Enjoy the trip. I have done it. I - 10 W goes to Santa Monica.