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Port St. Lucie
I would go North on I 75 to Port Huron. Then drive through Toronto, through Canada to Burlington. Stay on the paid toll through Toronto. Visit the 1000 Islands on the St. Lawrence Seaway. Take a boat tour. Then on to Burlington via Canada.
If you like the route and saw other things on the way, visit them on the return. I would stop by Mackinac Island, Traverse City, Silver Lake. Indiana Dunes, Chicago Navy Pier. I would stay in Madison, WI and go on I 90. Stop in Mitchell, SD. Stay in Rapid City. Go to Custer State Park, Needles Highway, Crazy Horse. Then to Mt. Rushmore. South Dakota highways are beautiful. It is an amazing place.