Niagara Falls (New York), Lewiston (New York), downtown Buffalo. It depends on what interests you and the time of year you are here. There are airbnb opportunities in Lewiston which is on the Niagara River. You can take jet boat rides, Maid of the Mist at the Falls etc. In downtown Buffalo there's lots to do and beautiful architecture including Frank Lloyd Wright's Martin House. There is also very close proximity to Canada and you can cross the border and go to the Canadian side of the falls and go to Niagara-on-the-Lake, the Niagara Wine trail, the Butterfly Conservatory etc. The region also has fabulous restaurants.