Hi Heather, Here are my suggestions for a road trip from Boston to Louisville: 1. Drive to Brandywine Creek Campground I assume you will need an RV campground to stay for a night or two. You may want to check out their website. Currently, camping is not allowed. It's about a 5.5 hour drive from Boston, depending on traffic. 2. Visit Valley Forge National Historical Park Longwood Gardens and Brandywine Battlefield Historic Site - all within 20-25 miles from Brandywine Creek Campground. Pennsylvania Dutch and Amish country are about 15 minutes away. 3. Next stop is Morgantown , WV, about a 4.5 hour drive. There are a couple of RV campgrounds. I found two - Sand Spring Campground and Morgantown Campground. 4. Things to do: visit Laurel Caverns (about 35 minutes from the Sand Springs Camping Area) and go whitewater rafting or rock climbing with Cheat River Outfitters. 5. Drive to Louisville, about a 6.5-hour drive from Morganstown.