Sample itinerary by car
Aside from visiting the Inner Harbor, Fells Point, Canton, Federal Hill Park, and Cross Street Market. Make time for a Crab Feast.
Mentioned in this answer:
I would go via Roanoke, Knoxville, Memphis and Hot Springs (or you could stop at Nashville but I'm not a Nashville fan)
are you asking for places to eat? Or how to drive through Baltimore? Places to visit? Or what? Let me know!