Chicago: Hip hotels, eats, shops, and spas for girls' weekend?
Hotel Felix Chicago in the near north is an amazing boutique hotel.
San Francisco: Best seafood restaurant in S.F.?
If you are into peruvian food
in Fillmore is an amazing restaurant with plenty of ceviche options that are a complete delight.
Also there is
in Pier 1.5 that could be a little up...