Just take the Trans-Canada Highway from Edmonton to Toronto then down to Windsor (Ontario)
AEdmonton: What's the best neighborhood in Edmonton for a first time visitor?
University/Whyte Ave area is fun during the day (boutiques and restaraunts) and lively at night (bars and university students). Very walkable area and pretty much the geographical center of the city.
AEdmonton: What is your favorite restaurant in Edmonton?
The Next Act for sandwiches/salads just off Whyte Ave Pampa Brazilian Steakhousefor Brazilian BBQ-downtown. Tres Carnales Taqueria- Mexican - Downtown