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St. Louis to Charleston drive

driving   /   2 days   /   no pets   /   no RV

St. Louis to Charleston road trip planner

Here's a sample itinerary for a drive from St. Louis to Charleston. If you're planning a road trip to Charleston, you can research locations to stop along the way. Make sure you check road conditions to double check the weather. Traveling with a dog or cat? Find pet-friendly stops. Camping along the way? Search for RV campgrounds. Find the best hotels, restaurants, and attractions based on the most talked about places recommended by Trippy members.

customize this trip
 Day 1

10:00 am  start in St. Louis
drive for about 1 hour

11:15 am  Mount Vernon (Illinois)
stay for about 1 hour
and leave at 12:15 pm
drive for about 2 hours

2:07 pm  Grand Rivers
stay for about 1 hour
and leave at 3:07 pm
drive for about 2 hours

4:57 pm  Nashville
stay overnight at Gaylord Opryland Resort
leave the next day around 8:00 am

day 1 driving ≈ 5 hours
find more stops

 Day 2

8:00 am  leave from Gaylord Opryland Resort
drive for about 3.5 hours

11:35 am  Gatlinburg
stay for about 1 hour
and leave at 12:35 pm
drive for about 1.5 hours

2:10 pm  Asheville
stay for about 2 hours
and leave at 4:10 pm
drive for about 1 hour

5:18 pm  Greenville (South Carolina)
stay for about 1 hour
and leave at 6:18 pm
drive for about 1.5 hours

7:51 pm  Columbia
stay for about 1 hour
and leave at 8:51 pm
drive for about 2 hours

10:39 pm  arrive in Charleston
stay at Vendue Inn

day 2 driving ≈ 9.5 hours
find more stops

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St. Louis to Charleston questions

profile  Judy asked:
stl to charleston  (5 answers)

profile  William asked:
The fastest route from St Louis to Charleston South Carolina.  (0 answers)


Where should I stop along the way?

Mount Vernon (Illinois)  (2 answers)
    questions about Mount Vernon (Illinois):
        I need Locals Advise

Grand Rivers  (2 answers)

Nashville  (190 answers)
    Grand Ole Opry  (8 mentions)
    Country Music Hall of Fame  (6 mentions)
    Ryman Auditorium  (6 mentions)
    Centennial Park  (6 mentions)
    The Parthenon  (5 mentions)
    restaurants around Nashville:
        Bluebird Cafe
        Opryland Hotel
        Pancake Pantry
        Hattie B's Hot Chicken - 19th Ave
        Peg Leg Porker BBQ
    hotels around Nashville:
        Gaylord Opryland Resort
        The Hermitage Hotel
        Omni Nashville Hotel
    questions about Nashville:
        What's the best neighborhood in Nashville for a first time visitor?
        Nearby small towns or outdoor areas?
        Top of the line hotels in Nashville?
        What are some must sees in Nashville during the weekend
        Best Location to Stay

Gatlinburg  (32 answers)
    Great Smoky Mountain National Park  (8 mentions)
    Great Smoky Mountains  (2 mentions)

Asheville  (83 answers)
    Biltmore Estate  (13 mentions)
    Wicked Weed Brewing  (6 mentions)
    Highland Brewing Company  (4 mentions)
    Wedge Brewing Company  (2 mentions)
    restaurants around Asheville:
        Tupelo Honey Cafe
        Wedge Brewing Co
        French Broad Chocolate Lounge
        C├║rate
        Asheville Brewing Company
    questions about Asheville:
        Short weekend in Asheville
        Dining and lodging on a budget?
        Bachelorette Party
        Where to stay and what to do in Asheville N. Carolina?
        Things to do and places to eat/drink during girls weekend?

Greenville (South Carolina)  (17 answers)
    Falls Park on the Reedy  (2 mentions)
    restaurants around Greenville (South Carolina):
        Coffee Underground
    questions about Greenville (South Carolina):
        Any good studying coffeeshops around Greenville?
        Best free things to do in Greenville?
        Pet friendly nice hotel

Columbia  (18 answers)
    Riverbanks Zoo and Garden  (2 mentions)


Where's the best place to stay in Charleston?

Are you going straight to a hotel, or looking for a vacation rental or Airbnb?

The best resource on neighborhoods, areas, and hotels is the Trippy page on where to stay in Charleston.

If you're looking for a quick answer, you can check out Vendue Inn, which was mentioned 8 times on Trippy.

Here are some more hotels people talk about:

Charleston Place Hotel  (7 mentions)
The Mills House Hotel  (4 mentions)
Francis Marion Hotel  (4 mentions)
Market Pavilion Hotel  (4 mentions)

Want to research more popular hotels in Charleston? Click the blue button below.




Where's the best place to eat in Charleston?

Need some recommendations on somewhere to get food?

Trippy members suggest Husk, which was mentioned 17 times.

Here are some more restaurants people talk about:

Hominy Grill  (11 mentions)
FIG  (7 mentions)

Want to research more popular restaurants in Charleston? Click the blue button below.




What are some things to do in Charleston?

This section could be endless, so rather than trying to suggest every local activity or attraction, we'll leave it open-ended.

These are some of the places people talk about on Trippy:

King Street  (8 mentions)
Boone Hall Plantation  (6 mentions)
The Battery  (6 mentions)
Folly Beach  (5 mentions)
Waterfront Park  (5 mentions)

Of course, Trippy is the perfect place to ask questions because there's an entire community of travelers talking to each other and sharing tips and advice. Trippy is where you can get answers personalized for your tastes, budgets, trip dates & more!

For example, here are some questions people have asked about Charleston. Click on any question to see answers from the community!

profile  Christa from Chicago asked:
Two day trip - what are the must sees, eats, and drinks?  (12 answers)

profile  Cindy from asked:
Best oceanfront place to stay closest to Charleston SC  (7 answers)

profile  Rod from Sebastopol asked:
Dinner with family in Charleston tonight...  (6 answers)

profile  Liz from Denver asked:
Afternoon in Charleston  (5 answers)

profile  Brett from Long Beach asked:
Newbie in Charleston, How to Spend an Afternoon  (5 answers)

Click the button below to explore more questions and answers related to Charleston.




Do I really have to go back home?

Yes, even this step is optional, because if you're on vacation who wants the trip to end? It's okay, you can start planning your next trip!

Want to plan the trip back? Get the reverse directions for a Charleston to St. Louis drive, or go to the main page to plan a new road trip.

You can also compare the travel time if you're flying or driving by calculating the distance from St. Louis to Charleston. Or get a full St. Louis to Charleston flight plan.

Don't forget about exploring your own hometown with a staycation. You can also find some cool day trips or get away for a weekend. Maybe try typing in a faraway location like London, Hong Kong, or Sydney, and get inspired for your dream trip around the world.

And if you know St. Louis well, please help your fellow travelers and answer their questions about St. Louis!





At a Glance
without making any stops
total driving distance is 857 miles
driving time of 12 hours, 37 minutes
Charleston is 1 hour ahead of St. Louis
93 St. Louis travel answers
2 Mount Vernon (Illinois) travel answers
2 Grand Rivers travel answers
190 Nashville travel answers
32 Gatlinburg travel answers
83 Asheville travel answers
17 Greenville (South Carolina) travel answers
18 Columbia travel answers
138 Charleston travel answers





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