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Saint Petersburg (Florida) to Key West via Fort Myers Beach

driving   /   2 days   /   no pets   /   no RV

Saint Petersburg (Florida) to Key West road trip planner

Here's a sample itinerary for a drive from Saint Petersburg (Florida) to Key West. If you're planning a road trip to Key West, you can research locations to stop along the way. Make sure you check road conditions to double check the weather. Traveling with a dog or cat? Find pet-friendly stops. Camping along the way? Search for RV campgrounds. Find the best hotels, restaurants, and attractions based on the most talked about places recommended by Trippy members.

customize this trip
 Day 1

11:00 am  start in Saint Petersburg (Florida)
drive for about 2 hours

1:15 pm  Fort Myers Beach
stay for about 1 hour
and leave at 2:15 pm
drive for about 2.5 hours

4:38 pm  Hollywood (Florida)
stay overnight at Hyatt Regency Pier Sixty-Six
leave the next day around 11:00 am

day 1 driving ≈ 4.5 hours
find more stops

 Day 2

11:00 am  leave from Hyatt Regency Pier Sixty-Six
drive for about 1.5 hours

12:38 pm  Key Largo
stay for about 1 hour
and leave at 1:38 pm
drive for about 1 hour

2:46 pm  Marathon
stay for about 1 hour
and leave at 3:46 pm
drive for about 1 hour

4:48 pm  arrive in Key West
stay at Casa Marina, A Waldorf Astoria Resort

day 2 driving ≈ 4 hours
find more stops

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Where should I stop along the way?

Fort Myers Beach  (4 answers)

Hollywood (Florida)  (6 answers)
    Collins Ave  (7 mentions)
    Las Olas Boulevard  (6 mentions)
    Las Olas Riverfront  (5 mentions)
    Aventura Mall  (4 mentions)
    Publix  (3 mentions)
    restaurants around Hollywood (Florida):
        15th Street Fisheries
        Bimini Boatyard Bar & Grill
        Le Cafe De Paris
    hotels around Hollywood (Florida):
        Hyatt Regency Pier Sixty-Six

Key Largo  (11 answers)
    questions about Key Largo:
        Restaurant Recommendations?
        What is your favorite restaurant in Key Largo?
        What's the best neighborhood in Key Largo for a first time visitor?

Marathon  (6 answers)


Where's the best place to stay in Key West?

Are you going straight to a hotel, or looking for a vacation rental or Airbnb?

The best resource on neighborhoods, areas, and hotels is the Trippy page on where to stay in Key West.

If you're looking for a quick answer, you can check out Casa Marina, A Waldorf Astoria Resort, which was mentioned 2 times on Trippy.

Here are some more hotels people talk about:

Want to research more popular hotels in Key West? Click the blue button below.




Where's the best place to eat in Key West?

Need some recommendations on somewhere to get food?

Trippy members suggest Blue Heaven Restaurant, which was mentioned 8 times.

Here are some more restaurants people talk about:

Louie's Backyard  (3 mentions)
Half Shell Raw Bar  (3 mentions)
Garbo's Grill  (2 mentions)
Hot Tin Roof  (2 mentions)

Want to research more popular restaurants in Key West? Click the blue button below.




What are some things to do in Key West?

This section could be endless, so rather than trying to suggest every local activity or attraction, we'll leave it open-ended.

These are some of the places people talk about on Trippy:

Duval Street  (3 mentions)
Mallory square  (3 mentions)
Sloppy Joe's Bar  (2 mentions)

Of course, Trippy is the perfect place to ask questions because there's an entire community of travelers talking to each other and sharing tips and advice. Trippy is where you can get answers personalized for your tastes, budgets, trip dates & more!

For example, here are some questions people have asked about Key West. Click on any question to see answers from the community!

profile  Cathy from Michigan asked:
Good hotel and things to do with 8 year old son.  (4 answers)

profile  ross from Chicago asked:
Great non touristy restaurants in key west  (3 answers)

profile  Bernadette from Ohio asked:
Driving from Miami to key west- where to stop and eat?  (2 answers)

profile  Karisa from Atlanta asked:
Things to do and places to eat/drink in Key West?  (2 answers)

profile  Tim from River Ridge, Louisiana asked:
Key West on a budget  (2 answers)

Click the button below to explore more questions and answers related to Key West.




Do I really have to go back home?

Yes, even this step is optional, because if you're on vacation who wants the trip to end? It's okay, you can start planning your next trip!

Want to plan the trip back? Get the reverse directions for a Key West to Saint Petersburg (Florida) drive, or go to the main page to plan a new road trip.

You can also compare the travel time if you're flying or driving by calculating the distance from Saint Petersburg (Florida) to Key West. Or get a full Saint Petersburg (Florida) to Key West flight plan.

Don't forget about exploring your own hometown with a staycation. You can also find some cool day trips or get away for a weekend. Maybe try typing in a faraway location like London, Hong Kong, or Sydney, and get inspired for your dream trip around the world.

And if you know Saint Petersburg (Florida) well, please help your fellow travelers and answer their questions about Saint Petersburg (Florida)!





At a Glance
without making any stops
total driving distance is 426 miles
driving time of 7 hours, 35 minutes
30 Saint Petersburg (Florida) travel answers
4 Fort Myers Beach travel answers
6 Hollywood (Florida) travel answers
11 Key Largo travel answers
6 Marathon travel answers
64 Key West travel answers





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