Here's a sample itinerary for a drive from Gatlinburg to Louisville. If you're planning a road trip to Louisville, you can research locations to stop along the way. Make sure you check road conditions to double check the weather. Traveling with a dog or cat? Find pet-friendly stops. Camping along the way? Search for RV campgrounds. Find the best hotels, restaurants, and attractions based on the most talked about places recommended by Trippy members.
11:00 am start in Gatlinburg
drive for about 2 hours
1:05 pm Middlesboro
stay overnight and leave the next day around 11:00 am
day 1 driving ≈ 2 hours
find more stops
11:00 am leave from Middlesboro
drive for about 2.5 hours
1:20 pm Lexington
stay for about 1 hour
and leave at 2:20 pm
drive for about 1.5 hours
3:45 pm arrive in Louisville
stay at 21C Museum Hotel
day 2 driving ≈ 4 hours
Lexington (28 answers)
questions about Lexington:
What is your favorite restaurant in Lexington?
Best place to stay in Lexington while attending the Rolex 3 day event?
stays overnight, Lexington, Ky. near highway
Are you going straight to a hotel, or looking for a vacation rental or Airbnb?
The best resource on neighborhoods, areas, and hotels is the Trippy page on where to stay in Louisville.
If you're looking for a quick answer, you can check out 21C Museum Hotel, which was mentioned 3 times on Trippy.
Here are some more hotels people talk about:
Want to research more popular hotels in Louisville? Click the blue button below.
Need some recommendations on somewhere to get food?
Trippy members suggest Seviche, A Latin Restaurant, which was mentioned 3 times.
Here are some more restaurants people talk about:
Want to research more popular restaurants in Louisville? Click the blue button below.
This section could be endless, so rather than trying to suggest every local activity or attraction, we'll leave it open-ended.
These are some of the places people talk about on Trippy:
Of course, Trippy is the perfect place to ask questions because there's an entire community of travelers talking to each other and sharing tips and advice. Trippy is where you can get answers personalized for your tastes, budgets, trip dates & more!
For example, here are some questions people have asked about Louisville. Click on any question to see answers from the community!
Katie from Los Angeles asked:
What's the best neighborhood in Louisville for a first time visitor? (10 answers)
Valerie from Los Angeles asked:
What is your favorite restaurant in Louisville? (9 answers)
Nicole from asked:
Any cool things to do/places to eat in Louisville? (6 answers)
Sasha from Houston asked:
Hotels to stay at during the Kentucky Derby? (2 answers)
Angi from Logansport, Indiana asked:
Has anyone been to Butchertown Market? (1 answer)
Click the button below to explore more questions and answers related to Louisville.
Yes, even this step is optional, because if you're on vacation who wants the trip to end? It's okay, you can start planning your next trip!
Want to plan the trip back? Get the reverse directions for a Louisville to Gatlinburg drive, or go to the main page to plan a new road trip.
You can also compare the travel time if you're flying or driving by calculating the distance from Gatlinburg to Louisville. Or get a full Gatlinburg to Louisville flight plan.
Don't forget about exploring your own hometown with a staycation. You can also find some cool day trips or get away for a weekend. Maybe try typing in a faraway location like London, Hong Kong, or Sydney, and get inspired for your dream trip around the world.
And if you know Gatlinburg well, please help your fellow travelers and answer their questions about Gatlinburg!
More info on this route: